Table 2 Type I PKSs found in animal lineage

Homo sapiens

Human

-

-

Homo sapiens GRCh37.p13

-

-

-

Bos taurus

Cattle

-

-

Bos taurus UMD3.

-

-

-

Canis (lupus) familiaris

Dog

-

-

Canis lupus familiaris CanFam3.1

-

-

-

Tursiops truncatus

Dolphin

-

-

Tursiops truncatus turTur1

-

-

-

Mus musculus

Mouse

-

-

Mus musculus GRCm38.p1

-

-

-

✓

Monodelphis domestica

Opossum

PREDICTED: phthioceranic/hydroxyphthioceranic acid synthase-like

XP_001375980

MonDom5

LOC100024851

no

KS-AT-DH-KR-ACP

✓

Sarcophilus harrisii

Tasmanian devil

mycocerosic acid synthase-like [Sarcophilus harrisii (Tasmanian devil)]

XP_003771909

Devil_refv7.0

LOC100922065

N.A

KS-AT-DH-KR-ACP

Ornithorhynchus anatinus

Platypus

LOC100091954 fatty acid synthase-like [Ornithorhynchus anatinus (platypus)]

-

Ornithorhynchus_anatinus-5.0.1

LOC100091954 (pseudo gene)

N.A

N.A (pseudo gene)

✓

Gallus gallus

Chicken

PREDICTED: phthioceranic/hydroxyphthioceranic acid synthase-like is oformX2 [Gallus gallus].

XP_418588

Gallus_gallus-4.0

LOC420486

Yes (brain; connective, blood)

KS-AT-DH-KR-ACP

✓

Taeniopygia guttata

Zebra finch

PREDICTED: phthioceranic/hydroxyphthioceranic acid synthase-like [Taeniopygia guttata].

XP_002189754

Taeniopygia_guttata-3.2.4

LOC100231542

No

KS-AT-DH-KR-ACP

PREDICTED: Taeniopygia guttata phthioceranic/hydroxyphthioceranic acid synthase-like

XP_002190558

LOC100222288

N.A

KS-AT-DH-KR-ACP

✓

Falco peregrinus

Peregrine falcon

PREDICTED: probable polyketide synthase 1-like [Falco peregrinus].

XP_005234016

F_peregrinus_v1.0

LOC101916009

N.A

KS-AT-DH-KR-ACP

✓

Anolis carolinensis

Green anole

PREDICTED: phthioceranic/hydroxyphthioceranic acid synthase-like [Anolis carolinensis].

XP_003222100

AnoCar2.0

LOC100564455

No

KS*-AT-DH-KR-ACP

PREDICTED: phthioceranic/hydroxyphthioceranic acid synthase-like [Anolis carolinensis].

XP_0032222101

LOC100564655

No

KS-AT-DH-KR-ACP

PREDICTED: phthioceranic/hydroxyphthioceranic acid synthase-like [Anolis carolinensis].

XP_0032222102

LOC100564856

No

KS-AT-DH-KR-ACP

✓

Chelonia mydas

Green sea turtle

Phthioceranic/hydroxyphthioceranic acid synthase [Chelonia mydas].

EMP37033

CheMyd_v1.0

locus_tag: UY3_05838

N.A

KS-AT-DH-KR-ACP

Polyketide synthase Pks N [Chelonia mydas]

EMP24664

locus_tag: UY3_18267

N.A

KS*-AT-DH-KR-ACP

✓

Chrysemys picta

Painted turtle

PREDICTED: uncharecterized protien LOC101936604 [Chrysemys picta bellii]

XP_005291085

Chrysemys_picta_bellii-3.0.1

LOC101936604

N.A

KS-AT*-DH*-KR-ACP

PREDICTED: uncharecterized protien LOC101937174 [Chrysemys picta bellii]

XP_005291087

LOC1019371714

N.A

other-KS-AT*-DH*-KR-ACP

✓

Pelodiscus sinensis

Chinese soft shell turtle

pep: KNOWN_BY_PROJECTION_protein_coding

Scaffold no. JH209275.1

PelSin_1.0

ENSPSIG00000004874

No

KS*-AT-DH-KR-ACP

Xenopus (Silurana) tropicalis

Tropical clawed toad

-

-

Xenopus (Silurana) tropicalis build 1 genome database (v4.2 assembly)

-

-

-

✓

Oryzias latipes

Medaka

OIPKS (PREDICTED: phthioceranic/hydroxyphthioceranic acid synthase-like [Oryzias latipes])

XP_004081385

Oryzias latipes ASM31367v1

LOC101169887

No

KS-AT-DH-KR-ACP

OIPKS-2 (PREDICTED: phthioceranic/hydroxyphthioceranic acid synthase type I P ps D-like [Oryzias latipes])

XP_004081384

LOC101169644

No

KS-AT-DH*-KR-ACP

OIPKS-3 (PREDICTED: probable polketide synthase 1-like [Oryzias latipes])

XP_004080917

LOC101170716

No

KS-AT-DH*-KR-ACP

✓

Danio rerio

Zebrafish

Danio rerio wu:fc01d11 (wu: fc01d11),mRNA

XP_682975

Danio rerio Zv9

wu:fc01d11

Yes (muscle)

KS-AT-DH-KR-ACP

si: dkey-61p9.11

NP_001041530

LOC100000781

Yes (kidney)

KS-AT-DH-KR-ACP

✓

Takifugu rubripes

Fugu

phthioceranic/hydroxyphthioceranic acid synthase-like

XP_003968201

FUGU5

LOC101079294

No

KS-AT-DH-KR-ACP

PREDICTED: Takifugu rubripes lovastatin nonaketide synthase-like (LOC101079519), mRNA

XP_003968202

LOC101079519

No

KS-AT-DH-KR-ACP

Petromyzon marinus

Lamprey

-

-

Pmarinus_7.0

-

-

-

✓

Branchiostoma Floridae

Lancelet

hypothetical protien BRAFLDRAFT_205831, partial [Branchiostoma floridae].

XP002599684 (=EEN55696)

Branchiostoma floridae v1.0

Gene ID:7231796

N.A.

KS-AT-DH-KR

hypothetical protien BRAFLDRAFT_247081 [Branchiostoma floridae]

XP_002591573

Gene ID:7219804

N.A.

KS-AT-DH*-KR

hypothetical protien BRAFLDRAFT_90481 [Branchiostoma floridae]

XP_002589799

Gene ID:7210376

N.A.

KS-AT-DH*-KR-AMP

hypothetical protien BRAFLDRAFT_96868 [Branchiostoma floridae]

XP_002598386

Gene ID:7254845

N.A.

KS-AT-DH-KR*-TE-C-AMP

hypothetical protien BRAFLDRAFT_96863 [Branchiostoma floridae]

XP_002598380

Gene ID:7248951

N.A.

KS-AT-DH-KR*-ACP-TE-C-AMP

hypothetical protien BRAFLDRAFT_87472 [Branchiostoma floridae]

XP_002589000

Gene ID:7246004

N.A.

KS-AT-DH-KR*-ACP-C-AMP

hypothetical protien BRAFLDRAFT_125690 [Branchiostoma floridae]

XP_002610053

Gene ID:7207083

N.A.

KS*-AT-DH-KR*-ACP*-TE-C

hypothetical protien BRAFLDRAFT_91451 [Branchiostoma floridae]

XP_002608071

Gene ID:7214024

N.A.

KS-AT-DH-MT-ADH-KR-ACP-α

hypothetical protien BRAFLDRAFT_87410 [Branchiostoma floridae]

XP_002605916

Gene ID:7243248

N.A.

KS-AT-DH-MT-ADH-KR-ACP

hypothetical protien BRAFLDRAFT_89867 [Branchiostoma floridae]

XP_002610100

Gene ID:7206066

N.A.

KS-AT-DH-MT-ADH-KR-ACP

hypothetical protien BRAFLDRAFT_87413 [Branchiostoma floridae]

XP_002605913

Gene ID:7246000

N.A.

KS-AT-DH-MT-ADH-KR-ACP

hypothetical protien BRAFLDRAFT_125650 [Branchiostoma floridae]

XP_002610103

Gene ID: 7207596

N.A.

AMP-KS-AT-DH-MT-ADH-KR-ACP

hypothetical protien BRAFLDRAFT_71890 [Branchiostoma floridae]

XP_002613500

Gene ID: 7224978

N.A.

KS*-AT-DH

✓

Saccoglossus kowalevskii

Acorn worm

PREDICTED: fatty acids synthase-like

XP_002734101

Skow_1.1

LOC100373061

N.A

KS*-AT-DH-KR-ACP-C-AMP

Ciona intestinalis

Ascidian

-

-

Ciona intestinalis KH

-

-

-

✓

Strongy locentrotus purpuratus

Purple sea urchin

LOC588806 probable polyketide synthase 1-like [Strongylocentrotus purpuratus (purple sea urchin)]

XP_793564.2

Spur_3.1

LOC58806

Yes

KS-AT*-DH*-MT-ADH-KR*-ACP

LOC592147 polyketide synthase 2

NP_001239013.1

LOC592147

Yes

KS-AT-DH*-KR-ACP-TE

✓

Acropora digitifera

Coral

aug_v2a.12941.t1 aug_v2a.12941scaf5202:2805-26950(−)

aug_v2a.12941

Adig_1.0

aug_v2a.12941

N.A.

other-KS-AT-DH-KR-ACP*-TE

aug_v2a.16843.t1 aug_v2a.16843scaf8086:11276-29700(−)

aug_v2a.16843

aug_v2a.16843

N.A.

other-KS-AT-DH-KR-TE

aug_v2a.16847.t1 aug_v2a.16847scaf8086:95926-115499(−)

aug_v2a.16847

aug_v2a.16847

N.A.

other-KS-AT-DH-KR-TE

Nematostella vectensis

Sea anemone

-

-

Nematostella vectensis v1.0

-

-

-

Hydra magnipapillata

Hydra

-

-

Hydra magnipapillataHydra_RP_1.0

-

-

-

Amphimedon queenslandica

Sponges

-

-

Amphimedon queenslandicav1.0

-

-

-

✓

Caenorhabditis elegans

Nematode

Protein C41A3.1 [Caenorhabditiselegans]

NP_508923

Caenorhabditis elegansWBcel235

C41A3.1

Yes

KS-KS-DH-ACP-KS-ACP-ACP-KR-ACP-AT-DH-KS-KR-KS-AT-ADH-ACP-C-AMP-ACP-TE

Drosophila melanogaster

Fruit fly

-

-

Drosophila melanogasterRelease 5

-

-

-