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Fig. 7 | Zoological Letters

Fig. 7

From: Involvement of Slit–Robo signaling in the development of the posterior commissure and concomitant swimming behavior in Xenopus laevis

Fig. 7

slit2/robo2-MO injected larvae change the width of the posterior commissure. a, b, d, e dorsal views of the tadpole brain at stage 44. a In slit2-control-MO injected larva, three commissures (habenular commissure: HC, posterior commissure: PC and cerebellar commissures: CC) are observed. PC indicated by an arrowhead. b In Slit2-MO injected larva, morphology of the habenular and cerebellar commissure appear to be normal, whereas nerve bundle of the posterior commissure become wider than the control larva (open arrowhead). c Quantification of the width of nerve bundle in Slit2-control- (blue)/Slit2-MO (red). slit2-MO-injected larva is significantly changed the width of the posterior commissure compared to that of slit2-control-MO (**P < 0.01). d, e In robo2-control- (D)/robo2-MO (e) injected larvae, the former represents three commissures but the latter shows unclear PC bundle (open arrowhead). f Quantification of the width of three commissures. The posterior commissure of robo2-MO-injected larva is significantly changed the width of the PC. Error bars are shown as standard deviation (SD). *P value was obtained by ANOVA (P < 0.05 is significant). (**P < 0.01). Scale bars: 200 μm

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