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Table 1 Efficacy of typical ROR ligands in mammals for medaka RORd1

From: A fourth subtype of retinoic acid receptor-related orphan receptors is activated by oxidized all-trans retinoic acid in medaka (Oryzias latipes)

Ligand Efficacy against EtOH (%)
20α-hydroxycholesterol 1.57 ± 0.06
7α-hydroxycholesterol 1.25 ± 0.01
7β-hydroxycholesterol 1.22 ± 0.00
7-ketocholesterol 1.27 ± 0.06
cholesterol ND
22R–hydroxycholesterol ND
25-hydroxycholesterol 1.55 ± 0.11
  1. ND not detected