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Table 2 Efficacy and potency of physiologically active substance for medaka RORd1

From: A fourth subtype of retinoic acid receptor-related orphan receptors is activated by oxidized all-trans retinoic acid in medaka (Oryzias latipes)

  Ligand Efficacy against EtOH (%) Potency (nM)
Steroid estradiol 1.73 ± 0.21 NC
17-hydroxyprogesterone 1.62 ± 0.14 NC
androstenedione 1.26 ± 0.06 NC
Indoleamine derivative melatonin 1.37 ± 0.08 NC
Thyroid hormone triiodothyronine (T3) −0.154 ± 0.03 NC
Retinoid all-trans retinoic alcohol (VA) 1.29 ± 0.04 NC
all-trans retinoic aldehyde (retinal) 1.95 ± 0.06 NC
all-trans retinoic acid (ATRA) 2.90 ± 0.18 NC
11-cis retinoic alcohol 1.67 ± 0.14 NC
11-cis retinoic aldehyde 2.37 ± 0.14 NC
11-cis retinoic acid 2.84 ± 0.15 NC
9-cis retinoic acid 2.39 ± 0.08 NC
13-cis retinoic acid 1.98 ± 0.23 NC
all-trans 4-hydroxyretinoic acid 3.07 ± 0.20 539 ± 97.3
all-trans 4-ketoretinoic acid 3.26 ± 0.28 737 ± 47.3
all-trans 5,6-epoxyretinoic acid 2.81 ± 0.31 NC
  1. NC not calculable