Table 2 Efficacy and potency of physiologically active substance for medaka RORd1

Steroid

estradiol

1.73 ± 0.21

NC

17-hydroxyprogesterone

1.62 ± 0.14

NC

androstenedione

1.26 ± 0.06

NC

Indoleamine derivative

melatonin

1.37 ± 0.08

NC

Thyroid hormone

triiodothyronine (T3)

−0.154 ± 0.03

NC

Retinoid

all-trans retinoic alcohol (VA)

1.29 ± 0.04

NC

all-trans retinoic aldehyde (retinal)

1.95 ± 0.06

NC

all-trans retinoic acid (ATRA)

2.90 ± 0.18

NC

11-cis retinoic alcohol

1.67 ± 0.14

NC

11-cis retinoic aldehyde

2.37 ± 0.14

NC

11-cis retinoic acid

2.84 ± 0.15

NC

9-cis retinoic acid

2.39 ± 0.08

NC

13-cis retinoic acid

1.98 ± 0.23

NC

all-trans 4-hydroxyretinoic acid

3.07 ± 0.20

539 ± 97.3

all-trans 4-ketoretinoic acid

3.26 ± 0.28

737 ± 47.3

all-trans 5,6-epoxyretinoic acid

2.81 ± 0.31

NC