Fig. 1
From: The role of clockwork orange in the circadian clock of the cricket Gryllus bimaculatus
Structural and phylogenetic analysis of Gryllus bimaculatus clockwork orange (Gb’cwo). a: Schematic structure of various CWO or DEC proteins, comparing the organization of the bHLH and Hairy ORANGE domains. b: A phylogenetic neighbor-joining tree of known insect CWO proteins and mammalian homologues (DEC proteins). The GenBank accession numbers are indicated in brackets. The reference bar indicates distance as the number of amino acid substitutions per site. c: The deduced structure of the Gb’cwo gene. Exons 1–8 of Gb’cwo are indicated by black bars, and other genes located near Gb’cwo are shown in different color bars. Red bars indicate the E-boxes located upstream, downstream, and in intron regions of Gb’cwo. See text for details